During the hiatus of Destiny's Child, Knowles released her debut solo album, Dangerously in Love, in 2003, which spawned two number-one singles on the Billboard Hot 100—"Crazy in Love" and "Baby Boy"—and became one of the most successful albums of that year, earning her a then record-tying five Grammy Awards. Following the disbandment of Destiny's Child in 2005, Knowles released her second solo album, B'Day, in 2006, which spawned the top 10 singles "Déjà Vu", "Irreplaceable" and "Beautiful Liar". Her third solo album I Am... Sasha Fierce (2008), spawned the hit singles "If I Were a Boy", "Single Ladies (Put a Ring on It)", "Halo" and "Sweet Dreams". The album helped Knowles earn six Grammys in 2010, breaking the record for most Grammy Awards won by a female artist in one night. Knowles' fourth solo album, 4 (2011), became her fourth consecutive number one album on the Billboard 200 as a solo artist. This made her the third artist in history to have her first four studio albums debut atop the chart.

Apart from her work in music, Knowles has also ventured into acting and designing clothes and perfumes. She made her acting debut in the musical film Carmen: A Hip Hopera (2001), prior to appearing in major films, including Austin Powers in Goldmember (2002), Dreamgirls (2006), which earned her two Golden Globe nominations, Cadillac Records (2008) and Obsessed (2009). In 2005, Knowles and her mother introduced their family's fashion line, House of Deréon, and in 2010, she released her first perfume, Heat. She has endorsed brands including, L'Oréal, Pepsi, Tommy Hilfiger, Nintendo and Vizio. In 2010, Knowles was ranked first on Forbes list of the "100 Most Powerful and Influential Musicians in the World", and second on its list of the "100 Most Powerful and Influential Celebrities in the World". In 2012, she was named "World's Most Beautiful Woman" by People magazine.

Knowles' work has earned her numerous awards and accolades, including 16 Grammy Awards, 11 MTV Video Music Awards, three American Music Awards, a Billboard Millennium Award, and a star on the Hollywood Walk of Fame with Destiny's Child. In 2009, Billboard named her the Top Radio Songs Artist of the 2000s decade, and ranked her as the 4th overall Artist of the Decade (and as the First Female Artist of that period). The Recording Industry Association of America (RIAA), also recognized Knowles as the Top Certified Artist of the 2000s. In the US, Knowles has sold over 11.2 million albums as of May 2010, and more than 30.4 million digital singles as of January 2012. She has sold 75 million records worldwide, making her one of the best-selling music artists of all time. Knowles appeared on VH1's 2010 list of the "100 Greatest Artists of All Time", and ranked third on their "100 Greatest Women in Music" list in 2012. In April 2008, Knowles married American rapper Jay-Z, and gave birth to their first child, Blue Ivy Carter, in January 2012.

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